SEGREGATION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II INFECTIONS BY ANTIBODY REACTIVITY TO UNIQUE VIRAL EPITOPES

被引：82
作者：
LIPKA, JJ
MIYOSHI, I
HADLOCK, KG
REYES, GR
CHOW, TP
BLATTNER, WA
SHAW, GM
HANSON, CV
GALLO, D
CHAN, L
FOUNG, SKH
机构：
[1] STANFORD UNIV,MED CTR,SCH MED,DEPT PATHOL,STANFORD,CA 94305
[2] GENELABS INC,DEPT MOLEC VIROL,REDWOOD CITY,CA
[3] GENELABS INC,DEPT ANALYT & PROC BIOCHEM,REDWOOD CITY,CA
[4] STATE CALIF DEPT HLTH SERV,CALIF VIRAL & RICKETTSIAL DIS LAB,BERKELEY,CA
[5] KOCHI MED SCH,DEPT MED,NANKOKU,KOCHI 78151,JAPAN
[6] NCI,ENVIRONM EPIDEMIOL BRANCH,BETHESDA,MD 20892
[7] UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL
[8] DIAGNOST BIOTECHNOL LTD,SINGAPORE,SINGAPORE
来源：
JOURNAL OF INFECTIOUS DISEASES | 1992年 / 165卷 / 02期
关键词：
D O I：
10.1093/infdis/165.2.268
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A recombinant protein of the human T cell lymphotropic virus type I (HTLV-I) gp46 outer membrane envelope, MTA-4 (residues 129-203), reacted by Western blot with sera from HTLV-I-infected individuals from the United States and Jamaica but not with 24 (10%) of 242 Japanese sera. A related gp46 recombinant protein, MTA-1 (residues 162-209), reacted with all 58 sera from HTLV-I-infected US and Jamaican individuals and 238 of 242 sera from infected Japanese (combined sensitivity of 99%). Neither recombinant showed reactivity to sera from HTLV-II-infected individuals or uninfected controls. The reactivity of recombinant proteins containing the region of HTLV-II gp46 analogous to MTA-1 was also evaluated by Western blot: GH2-K15 (residues 157-205) and GH2-K55 (residues 162-205) reacted with 88 (98%) and 89 (99%), respectively, of 90 sera from HTLV-II-infected individuals but not with sera from HTLV-I-infected individuals or uninfected controls. These recombinant proteins should permit the development of assays to unambiguously confirm and differentiate HTLV-I and HTLV-II infections.
引用
收藏
页码：268 / 272
页数：5
相关论文
共 25 条
[1]   THE HUMAN TYPE-C RETROVIRUS, HTLV, IN BLACKS FROM THE CARIBBEAN REGION, AND RELATIONSHIP TO ADULT T-CELL LEUKEMIA LYMPHOMA [J].
BLATTNER, WA ;
KALYANARAMAN, VS ;
ROBERTGUROFF, M ;
LISTER, TA ;
GALTON, DAG ;
SARIN, PS ;
CRAWFORD, MH ;
CATOVSKY, D ;
GREAVES, M ;
GALLO, RC .
INTERNATIONAL JOURNAL OF CANCER, 1982, 30 (03) :257-264
[2]   TYPE-SPECIFIC ANTIGENS FOR SEROLOGICAL DISCRIMINATION OF HTLV-I AND HTLV-II INFECTION [J].
CHEN, YMA ;
LEE, TH ;
WIKTOR, SZ ;
SHAW, GM ;
MURPHY, EL ;
BLATTNER, WA ;
ESSEX, M .
LANCET, 1990, 336 (8724) :1153-1155
[3]   SEQUENCE VARIANTS OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I FROM PATIENTS WITH TROPICAL SPASTIC PARAPARESIS AND ADULT T-CELL LEUKEMIA DO NOT DISTINGUISH NEUROLOGICAL FROM LEUKEMIC ISOLATES [J].
DAENKE, S ;
NIGHTINGALE, S ;
CRUICKSHANK, JK ;
BANGHAM, CRM .
JOURNAL OF VIROLOGY, 1990, 64 (03) :1278-1282
[4]   RETROVIRAL SEQUENCES RELATED TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-II IN PATIENTS WITH CHRONIC FATIGUE IMMUNE DYSFUNCTION SYNDROME [J].
DEFREITAS, E ;
HILLIARD, B ;
CHENEY, PR ;
BELL, DS ;
KIGGUNDU, E ;
SANKEY, D ;
WROBLEWSKA, Z ;
PALLADINO, M ;
WOODWARD, JP ;
KOPROWSKI, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) :2922-2926
[5]   ANTIBODIES TO HTLV-I IN NIGERIAN BLOOD-DONORS, THEIR RELATIVES AND PATIENTS WITH LEUKEMIAS, LYMPHOMAS AND OTHER DISEASES [J].
FLEMING, AF ;
MAHARAJAN, R ;
ABRAHAM, M ;
KULKARNI, AG ;
BHUSNURMATH, SR ;
OKPARA, RA ;
WILLIAMS, E ;
AKINSETE, I ;
SCHNEIDER, J ;
BAYER, H ;
HUNSMANN, G .
INTERNATIONAL JOURNAL OF CANCER, 1986, 38 (06) :809-813
[6]   DIRECT ACTIVATION OF RESTING LYMPHOCYTES-T BY HUMAN T-LYMPHOTROPIC VIRUS TYPE-I [J].
GAZZOLO, L ;
DODON, MD .
NATURE, 1987, 326 (6114) :714-717
[7]  
GESSAIN A, 1985, LANCET, V2, P407
[8]   IDENTIFICATION OF TYPE-SPECIFIC LINEAR EPITOPES IN THE GLYCOPROTEINS GP46 AND GP21 OF HUMAN T-CELL LEUKEMIA VIRUSES TYPE-I AND TYPE-II USING SYNTHETIC PEPTIDES [J].
HORAL, P ;
HALL, WW ;
SVENNERHOLM, B ;
LYCKE, J ;
JEANSSON, S ;
RYMO, L ;
KAPLAN, MH ;
VAHLNE, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (13) :5754-5758
[9]   THE ORIGIN OF JAPANESE HTLV-I [J].
ISHIDA, T ;
HINUMA, Y .
NATURE, 1986, 322 (6079) :504-504
[10]   A NEW SUBTYPE OF HUMAN T-CELL LEUKEMIA-VIRUS (HTLV-II) ASSOCIATED WITH A T-CELL VARIANT OF HAIRY-CELL LEUKEMIA [J].
KALYANARAMAN, VS ;
SARNGADHARAN, MG ;
ROBERTGUROFF, M ;
MIYOSHI, I ;
BLAYNEY, D ;
GOLDE, D ;
GALLO, RC .
SCIENCE, 1982, 218 (4572) :571-573
123