CORONAVIRUS INDUCED PRIMARY DEMYELINATION - INDICATIONS FOR THE INVOLVEMENT OF A HUMORAL IMMUNE-RESPONSE

被引:24
|
作者
ZIMPRICH, F
WINTER, J
WEGE, H
LASSMANN, H
机构
[1] AUSTRIAN ACAD SCI,EXPTL NEUROPATHOL RES UNIT,SCHWARZSPANIERSTR 17,A-1090 VIENNA,AUSTRIA
[2] UNIV WURZBURG,INST VIROL & IMMUNOL,W-8700 WURZBURG,GERMANY
[3] UNIV VIENNA,INST NEUROL,A-1010 VIENNA,AUSTRIA
关键词
CORONA VIRUS; MHV-JHM; SPIKE PROTEIN; ENCEPHALITIS; DEMYELINATION; REMYELINATION; HUMORAL IMMUNE RESPONSE;
D O I
10.1111/j.1365-2990.1991.tb00750.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Coronavirus MHV-JHM infection of rodents can result in demyelinating encephalomyelitis. We analysed histological changes induced by coronavirus MHV-JHM infection in Lewis rats. Besides an acute disease (AE), chronic panencephalitis (CPE) and subacute demyelinating encephalomyelitis (SDE) were induced. These disease types were differentiated by the incubation period, the localization of lesions, the type of tissue damage and distribution of virus antigen. In AE and CPE, virus antigen was detected in neurons, astrocytes and oligodendrocytes, whereas in SDE neurons lacked virus antigen. Viral nucleocapsid protein (N) was present in the cytoplasm and the spike protein (S) was displayed on the surface of infected neural cells. However, expression of S protein relative to N protein was severely impaired in SDE lesions. Quantitative analysis of infiltrating inflammatory cells revealed that the number of macrophages and T cells were similar in lesions of AE, CPE and SDE. In contrast to that, SDE lesions contained a significantly higher number of IgG + B cells and plasma cells. In addition active demyelinating SDE lesions displayed an enhanced IgG content and deposits of complement C9. These results indicate that virus induced primary demyelination could be a consequence of antibody mediated cytotoxicity. Furthermore, a reduction in the number of cells producing spike protein in the chronic forms of the disease indicates down-regulation of this protein, possibly mediated by anti-S antibodies.
引用
收藏
页码:469 / 484
页数:16
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