DECREASED CEREBRAL GLUCOSE-UTILIZATION IN MYOTONIC-DYSTROPHY

被引：45

作者：

FIORELLI, M

DUBOC, D

MAZOYER, BM

BLIN, J

EYMARD, B

FARDEAU, M

SAMSON, Y

机构：

[1] SERV HOSP FREDERIC JOLIOT,CEA,4 PL GEN LECLERC,F-91406 ORSAY,FRANCE

[2] HOP COCHIN,DIV CARDIOL,F-75674 PARIS 14,FRANCE

[3] HOP LA PITIE SALPETRIERE,MALADIES SYST NERVEUX CLIN,F-75651 PARIS 13,FRANCE

[4] INSERM,U153,F-75005 PARIS,FRANCE

来源：

NEUROLOGY | 1992年 / 42卷 / 01期

关键词：

D O I：

10.1212/WNL.42.1.91

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To test the hypothesis that cerebral metabolism is altered in myotonic dystrophy (MyD), we investigated cerebral glucose kinetics and utilization in 11 adult patients with MyD and 14 healthy controls, using F-18-labeled 2-fluoro-2-deoxy-D-glucose (FDG) and dynamic positron emission tomography. Estimation of rate constants in MyD revealed a reduction of FDG delivery to the brain. Cortical glucose utilization rate was reduced by about 20% in MyD. These findings may be related to the presence of neurologic impairment in MyD and prompt further investigations on the metabolic and clinical features of brain dysfunction in this disease.

引用

页码：91 / 94

页数：4

共 26 条

[11] DIMINISHED GLUCOSE-TRANSPORT IN ALZHEIMERS-DISEASE - DYNAMIC PET STUDIES [J].