DECREASED CEREBRAL GLUCOSE-UTILIZATION IN MYOTONIC-DYSTROPHY

被引：45
作者：
FIORELLI, M
DUBOC, D
MAZOYER, BM
BLIN, J
EYMARD, B
FARDEAU, M
SAMSON, Y
机构：
[1] SERV HOSP FREDERIC JOLIOT,CEA,4 PL GEN LECLERC,F-91406 ORSAY,FRANCE
[2] HOP COCHIN,DIV CARDIOL,F-75674 PARIS 14,FRANCE
[3] HOP LA PITIE SALPETRIERE,MALADIES SYST NERVEUX CLIN,F-75651 PARIS 13,FRANCE
[4] INSERM,U153,F-75005 PARIS,FRANCE
来源：
NEUROLOGY | 1992年 / 42卷 / 01期
关键词：
D O I：
10.1212/WNL.42.1.91
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
To test the hypothesis that cerebral metabolism is altered in myotonic dystrophy (MyD), we investigated cerebral glucose kinetics and utilization in 11 adult patients with MyD and 14 healthy controls, using F-18-labeled 2-fluoro-2-deoxy-D-glucose (FDG) and dynamic positron emission tomography. Estimation of rate constants in MyD revealed a reduction of FDG delivery to the brain. Cortical glucose utilization rate was reduced by about 20% in MyD. These findings may be related to the presence of neurologic impairment in MyD and prompt further investigations on the metabolic and clinical features of brain dysfunction in this disease.
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页码：91 / 94
页数：4
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