A RECEPTOR TYROSINE KINASE SPECIFIC TO HEMATOPOIETIC STEM AND PROGENITOR CELL-ENRICHED POPULATIONS

被引：553

作者：

MATTHEWS, W ^{[1
]}

JORDAN, CT ^{[1
]}

WIEGAND, GW ^{[1
]}

PARDOLL, D ^{[1
]}

LEMISCHKA, IR ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV, DEPT MED, BALTIMORE, MD 21205 USA

来源：

CELL | 1991年 / 65卷 / 07期

关键词：

D O I：

10.1016/0092-8674(91)90010-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To elucidate the molecular biology of the hematopoietic stem cell, we have begun to isolate genes from murine cell populations enriched in stem cell activity. One such cDNA encodes a novel receptor tyrosine kinase, designated fetal liver kinase-2 or flk-2, which is related to the W locus gene product c-kit. Expression analyses suggest an extremely restricted distribution of flk-2. It is expressed in populations enriched for stem cells and primitive uncommitted progenitors, and is absent in populations containing more mature cells. Therefore, this receptor may be a key signal transducing component in the totipotent hematopoietic stem cell and its immediate self-renewing progeny.

引用

页码：1143 / 1152

页数：10

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