A RECEPTOR TYROSINE KINASE SPECIFIC TO HEMATOPOIETIC STEM AND PROGENITOR CELL-ENRICHED POPULATIONS

被引：553
作者：
MATTHEWS, W [1 ]
JORDAN, CT [1 ]
WIEGAND, GW [1 ]
PARDOLL, D [1 ]
LEMISCHKA, IR [1 ]
机构：
[1] JOHNS HOPKINS UNIV, DEPT MED, BALTIMORE, MD 21205 USA
来源：
CELL | 1991年 / 65卷 / 07期
关键词：
D O I：
10.1016/0092-8674(91)90010-V
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To elucidate the molecular biology of the hematopoietic stem cell, we have begun to isolate genes from murine cell populations enriched in stem cell activity. One such cDNA encodes a novel receptor tyrosine kinase, designated fetal liver kinase-2 or flk-2, which is related to the W locus gene product c-kit. Expression analyses suggest an extremely restricted distribution of flk-2. It is expressed in populations enriched for stem cells and primitive uncommitted progenitors, and is absent in populations containing more mature cells. Therefore, this receptor may be a key signal transducing component in the totipotent hematopoietic stem cell and its immediate self-renewing progeny.
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页码：1143 / 1152
页数：10
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