ANTI-HORMONAL AGENTS .6. DIRECT PLASMA ANALYSIS OF TAMOXIFEN BY HPLC USING AN ONLINE ISRP EXTRACTION CARTRIDGE

被引：7
作者：
MATLIN, SA
THOMAS, C
VINCE, PM
机构：
[1] Chemistry Department, City University, London, EC IV, OHB, Northbampton Square
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY | 1990年 / 13卷 / 11期
关键词：
D O I：
10.1080/01483919008049028
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
HPLC analysis of the anti-estrogen tamoxifen can be achieved by direct injection of diluted plasma samples without pre-treatment. The method uses an additional HPLC pump and two injectors and involves in-line filtration and sample clean up on a loading loop cartridge containing an internal surface reverse phase packing, followed by elution on an ODS-silica column. The minimization of sample handling and avoidance of extraction and adsorption losses result in a very rapid and accurate procedure suitable for routine assays. © 1990, Taylor & Francis Group, LLC. All rights reserved.
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页码：2253 / 2260
页数：8
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