CYTOCHROME-P-450 MEDIATED METABOLISM OF PROGESTERONE BY ADRENAL MICROSOMES OF PCB-TREATED AND UNTREATED BARN OWL (TYTO-ALBA) AND MARSH TURTLE (MAUREMYS-CASPICA) IN COMPARISON WITH THE GUINEA-PIG

被引：10

作者：

GOLDMAN, D ^{[1
]}

YAWETZ, A ^{[1
]}

机构：

[1] TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,INST NAT CONSERVAT RES,IL-69978 TEL AVIV,ISRAEL

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1991年 / 99卷 / 1-2期

关键词：

D O I：

10.1016/0742-8413(91)90107-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Significant differences between species were observed in the profile of steroids produced from progesterone by adrenal microsomes as well as in the effects elicited by Aroclor 1254 on cytochrome P-450-mediated activities. 2. In the guinea-pig, the major metabolites were products of the corticosteroid pathway but products of the androgenic pathway were also detected; in the barn owl products of both pathways were also formed while in the marsh turtle only products of the corticosteroid pathway were detected. 3. The effect of Aroclor 1254 on P-450C21 activity in the turtle and barn owl was inductive in contrast to the inhibitory effect observed in the guinea-pig.

引用

页码：251 / 255

页数：5

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