STUDY ON VARIOUS POLYMORPHOUS FORMS OF MEPROBAMATE

被引：0

作者：

LEFEBVRE, C

GUILLAUME, F

BOUCHE, R

BOUAZIZ, R

GUYOT, JC

机构：

[1] CATHOLIC UNIV LOUVAIN,ANAL MED LAB,B-1348 LOUVAIN,BELGIUM

[2] FAC SCI & TECH ROUEN,CHIM MINERALE & STRUCT LAB,F-76130 MONT ST AIGNAN,FRANCE

[3] FAC PHARM LILLE,PHARMACOTECH IND LAB,F-59045 LILLE,FRANCE

来源：

PHARMACEUTICA ACTA HELVETIAE | 1991年 / 66卷 / 03期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Meprobamate is a drug which has a bad compressibility and a low solubility in water. In the literature, several crystalline forms of meprobamate have been characterized. In this work, three crystalline forms have been prepared with different technics of recrystallisation. These crystal modifications have been characterized by differential scanning calorimetry and by powder X ray diffractometry. Then, the authors have studied the solubilities and the dissolution rates of the forms. At last, they have compared their abilities to be compressed to those of different commercial samples of meprobamate.

引用

页码：90 / 96

页数：7

共 12 条

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