VASOACTIVE-INTESTINAL-PEPTIDE (VIP) REVERSES ENDOTHELIN-INDUCED CONTRACTIONS OF GUINEA-PIG TRACHEA AND PULMONARY-ARTERY

被引：8
作者：
BOOMSMA, JD
FODA, HD
SAID, SI
机构：
[1] UNIV ILLINOIS,COLL MED,CHICAGO,IL 60680
[2] VET ADM W SIDE MED CTR,CHICAGO,IL 60680
来源：
BIOMEDICAL RESEARCH-TOKYO | 1991年 / 12卷 / 04期
关键词：
D O I：
10.2220/biomedres.12.273
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Endothelin-1 (ET-1), a unique vasoconstrictor peptide, may play a role as a physiologic or pathologic mediator. The potent and sustained actions of exogenously administered ET-1 on smooth muscle raise the question of how these actions may be modulated when the peptide is released endogenously. We report here that vasoactive intestinal peptide (VIP), a widely distributed neuropeptide, can reverse the constrictor effect of ET-1 on guinea-pig tracheal smooth muscle segments and reduce ET-induced contractions of guinea-pig pulmonary artery segments. VIP may thus be one of the endogenous modulators of the actions of ET-1.
引用
收藏
页码：273 / 277
页数：5
相关论文
共 31 条
[1]   VASOACTIVE INTESTINAL PEPTIDE IS A PHYSIOLOGICAL MEDIATOR OF PROLACTIN-RELEASE IN THE RAT [J].
ABE, H ;
ENGLER, D ;
MOLITCH, ME ;
BOLLINGERGRUBER, J ;
REICHLIN, S .
ENDOCRINOLOGY, 1985, 116 (04) :1383-1390
[2]   FORMATION OF ENDOTHELIN BY CULTURED AIRWAY EPITHELIAL-CELLS [J].
BLACK, PN ;
GHATEI, MA ;
TAKAHASHI, K ;
BRETHERTONWATT, D ;
KRAUSZ, T ;
DOLLERY, CT ;
BLOOM, SR .
FEBS LETTERS, 1989, 255 (01) :129-132
[3]   IMMUNOREACTIVE ENDOTHELIN IN HUMAN-PLASMA - MARKED ELEVATIONS IN PATIENTS IN CARDIOGENIC-SHOCK [J].
CERNACEK, P ;
STEWART, DJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 161 (02) :562-567
[4]   THE ORIGINS, PATHWAYS AND TERMINATIONS OF NEURONS WITH VIP-LIKE IMMUNOREACTIVITY IN THE GUINEA-PIG SMALL-INTESTINE [J].
COSTA, M ;
FURNESS, JB .
NEUROSCIENCE, 1983, 8 (04) :665-676
[5]  
DEMAY JG, 1982, CIRC RES, V51, P439
[6]  
DENUCCI G, 1988, P NATL ACAD SCI USA, V85, P9797
[7]  
DEY RD, 1981, CELL TISSUE RES, V220, P231
[8]   THE OBLIGATORY ROLE OF ENDOTHELIAL-CELLS IN THE RELAXATION OF ARTERIAL SMOOTH-MUSCLE BY ACETYLCHOLINE [J].
FURCHGOTT, RF ;
ZAWADZKI, JV .
NATURE, 1980, 288 (5789) :373-376
[9]   VIP AS A POSSIBLE NEUROTRANSMITTER OF NON-CHOLINERGIC NON-ADRENERGIC INHIBITORY NEURONS [J].
GOYAL, RK ;
RATTAN, S ;
SAID, SI .
NATURE, 1980, 288 (5789) :378-380
[10]   VASOACTIVE INTESTINAL PEPTIDE - RELAXANT NEUROTRANSMITTER IN TENIA-COLI OF THE GUINEA-PIG [J].
GRIDER, JR ;
CABLE, MB ;
BITAR, KN ;
SAID, SI ;
MAKHLOUF, GM .
GASTROENTEROLOGY, 1985, 89 (01) :36-42
1234