LOSS OF BETA-ADRENOCEPTOR BINDING-SITES IN RAT STRIATUM FOLLOWING KAINIC ACID LESIONS

被引：29

作者：

NAHORSKI, SR ^{[1
]}

HOWLETT, DR ^{[1
]}

REDGRAVE, P ^{[1
]}

机构：

[1] UNIV SHEFFIELD, DEPT PSYCHOL, SHEFFIELD S10 2TN, S YORKSHIRE, ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 60卷 / 2-3期

关键词：

Kainic lesions; Striatum; β-Adrenoceptor subtypes;

D O I：

10.1016/0014-2999(79)90226-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intrastriatal injection of kainic acid (5 nmol) to rats led to a severe destruction of nerve cell bodies throughout the caudate-putamen complex and an extensive proliferation of glial cells. Lesioned striata displayed a significant 23% loss of .beta.-adrenoceptor binding sites 21-24 days after injection of kainic acid. Further analysis of the changes revealed that this loss of sites was selectively within the .beta.1 receptor population. The results do not rule out a partial glial cell localization for .beta.-adrenoceptors; they indicate that a proportion of .beta.1 receptors are present on striatal perikarya.

引用

页码：249 / 252

页数：4

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