Serum adiponectin level in osteoporotic postmenopausal women with type 2 diabetes mellitus

Background: Diabetes Mellitus (DM) is a major health burden worldwide. Patients with type 2 DM has various complications, including impaired bone health. Adiponectin is novel adipocytokine that could influence bone metabolism. Objective: We investigated the relationships between serum adiponectin versus lumbar bone mineral density (BMD) in type 2 diabetic osteoporotic postmenopausal women. Subjects and methods: This study is a case control study included 90 postmenopausal women; divided as (group A) composed of 30 type 2 diabetic osteoporotic postmenapausal,(group B) composed of 30 non diabetic osteoporotic postmenopausal and 30 apparently healthy non osteoporotic postmenopausal women as a control group. All participants underwent Dual Energy X-ray Absorptiometry to measure the lumbar Bone Mineral Density (BMD).Serum adiponectin was measured by ELISA Kits. SPSS was used to analyze the data. Results: Among the studied subjects, group B showed a significant negative correlation between serum adiponectin and lumbar BMD. The diabetic osteoporotic postmenapausal group (group B) showed the lowest concentration of serum adiponectin (mu g/mL): 5.14 compared with 11.02 and 8.63 in group A, and the control, respectively. Lumbar BMD of group B was significantly higher than that of group A. Conclusions: Serum adiponectin is associated with lumber BMD in diabetic osteoporotic postmenopausal women. These findings suggest that serum adiponectin was involved in bone metabolism in this group. (C) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.