HIGHLY STEREOCONTROLLED ASYMMETRIC SYNTHESES OF TAXOL AND TAXOTERE C-13 SIDE-CHAIN ANALOGS

被引：32

作者：

MUKAI, C ^{[1
]}

KIM, IJ ^{[1
]}

FURU, E ^{[1
]}

HANAOKA, M ^{[1
]}

机构：

[1] KANAZAWA UNIV,FAC PHARMACEUT SCI,TAKARA MACHI,KANAZAWA,ISHIKAWA 920,JAPAN

来源：

TETRAHEDRON | 1993年 / 49卷 / 37期

关键词：

D O I：

10.1016/S0040-4020(01)81916-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric aldol reaction of (+)-tricarbonyl(eta6-2-trimethylsilylbenzaldehyde)chromium(0) complex (4) with titanium enolate of S-tert-butyl benzyloxyethanethioate (10) provided, after consecutive desilylation and decomplexation, anti-aldol product 15 in a highly stereoselective manner. Anti-product 15 was subsequently converted to (2R,3S)-N-benzoyl- and N-tert-butoxycarbonyl-3-phenylisoserine methyl esters (23 and 24), C-13 side chain analogues of taxol (1) and taxotere (2).

引用

页码：8323 / 8336

页数：14

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