Acute Isoniazid Poisoning Mimicking Meningoencephalitis: Case Report and Review of Literature

被引：1

作者：

Kose, Ataman ^{[1
]}

Zenginol, Murat ^{[2
]}

Kose, Beril ^{[3
]}

Gunay, Nurullah ^{[4
]}

Yildirim, Cuma ^{[2
]}

机构：

[1] Van Egitim & Arastirma Hastanesi, Acil Serv Klin, Van, Turkey

[2] Gaziantep Univ, Tip Fak, Acil Tip Anabilim Dali, Gaziantep, Turkey

[3] Dr I Sevki Atasagun Devlet Hastanesi, Acil Serv Klin, Nevsehir, Turkey

[4] Kayseri Egitim & Arastirma Hastanesi, Acil Serv Klin, Kayseri, Turkey

来源：

EURASIAN JOURNAL OF EMERGENCY MEDICINE | 2011年 / 10卷 / 01期

关键词：

Meningoencephalitis; seizures; hepatotoxicity; isoniazid;

D O I：

10.4170/jaem.2009.17363

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Antituberculosis drug-induced intoxications, though at a diminished level, could still rarely occur in the present day. Isoniazid-induced seizures, hepatotoxicity, and neurotoxicity have been reported, usually as chronic side effects. In the present study, we report a case who was brought to our hospital unconscious with meningoencephalitis and who, following prolonged prognosis efforts, was determined to have developed neurotoxicity, recurring seizures, and hepatotoxicity due to attempted suicide by ingestion of a potentially lethal dose (300 mg INH*50 tablets; 15 gr) of isoniazid.

引用

页码：43 / 45

页数：3

共 11 条

[1] ISONIAZID OVERDOSE - 4 CASE-REPORTS AND REVIEW OF THE LITERATURE
ALVAREZ, FG
GUNTUPALLI, KK
[J]. INTENSIVE CARE MEDICINE, 1995, 21 (08) : 641 - 644
[2] Kilicaslan Z., 2007, ANKEM DERG, V21, P76
[3] Seizures in a 13-year-old girl
Knapp, JF
Johnson, T
Alander, S
[J]. PEDIATRIC EMERGENCY CARE, 2003, 19 (01) : 38 - 40
[4] Isoniazid overdose - A case series, literature review and survey of antidote availability
Maw, G
Aitken, P
[J]. CLINICAL DRUG INVESTIGATION, 2003, 23 (07) : 479 - 485
[5] Mechem CC, E MED J
[6] Acute isoniazid toxicity and the need for adequate pyridoxine supplies
Morrow, Lee E.
Wear, Robert E.
Schuller, Dan
Malesker, Mark
[J]. PHARMACOTHERAPY, 2006, 26 (10): : 1529 - 1532
[7] Osborn H., 2004, GOLDFRANKS TOXICOLOG, P627
[8] Romero JA, 1998, AM FAM PHYSICIAN, V57, P749
[9] Steinmann Rebecca A, 2002, J Emerg Nurs, V28, P7, DOI 10.1067/men.2002.117211
[10] Sullivan Elizabeth A., 1998, Journal of Emergency Medicine, V16, P57, DOI 10.1016/S0736-4679(97)00242-4

← 1 2 →