SYNTHESIS AND ELECTROCHEMICAL PROPERTIES OF THE NATURALLY-OCCURRING FREE-RADICAL SCAVENGER CARAZOSTATIN

被引：23

作者：

JACKSON, PM ^{[1
]}

MOODY, CJ ^{[1
]}

MORTIMER, RJ ^{[1
]}

机构：

[1] LOUGHBOROUGH UNIV TECHNOL,DEPT CHEM,LOUGHBOROUGH LE11 3TU,LEICS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 12期

关键词：

D O I：

10.1039/p19910002941

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short synthesis of the naturally occurring free radical scavenger carazostatin 1 starting from indol-3-ylacetic acid is described, the key step being the regiospecific Diels-Alder reaction of the indolopyrone 2 with ethyl trimethylsilylpropynoate. Electrochemical studies on carazostatin and some of its derivatives show it to be more easily oxidised than butylated hydroxytoluene (BHT).

引用

页码：2941 / 2944

页数：4

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