CORRELATIONS BETWEEN THEOPHYLLINE CONCENTRATIONS IN PLASMA, ERYTHROCYTES AND CANTHARIDES-INDUCED BLISTER FLUID AND PEAK EXPIRATORY FLOW IN ASTHMA PATIENTS

被引：8

作者：

PHILIPJOET, F ^{[1
]}

BRUGUEROLLE, B ^{[1
]}

REYNAUD, M ^{[1
]}

ARNAUD, A ^{[1
]}

机构：

[1] SCH MED MARSEILLE,CLIN & EXPTL PHARMACOL LAB,MARSEILLE,FRANCE

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 43卷 / 05期

关键词：

THEOPHYLLINE; ASTHMA; BLISTER FLUID; ERYTHROCYTES; FREE LEVELS; PEAK EXPIRATORY FLOW; PHARMACOKINETICS;

D O I：

10.1007/BF02285104

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Theophylline levels in plasma, erythrocytes and cantharides-induced blister fluid (BF) have been correlated with peak expiratory flow (PEF) in asthmatic patients. Nine asthmatic men received an IV infusion of 240 mg theophylline at a constant rate for 30 min. The theophylline concentrations in erythrocytes and blister fluid were 37 % and 78 % of those in plasma. There was not a strong correlation between erythrocyte or blister fluid penetration and the clinical effect of theophylline.

引用

页码：563 / 565

页数：3

共 4 条

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