PRODUCTION OF INTERLEUKIN-1-RECEPTOR ANTAGONIST DURING EXPERIMENTAL ENDOTOXEMIA

被引：309

作者：

GRANOWITZ, EV

SANTOS, AA

POUTSIAKA, DD

CANNON, JG

WILMORE, DW

WOLFF, SM

DINARELLO, CA

机构：

[1] TUFTS UNIV,NEW ENGLAND MED CTR,SCH MED,DEPT MED,750 WASHINGTON ST,BOSTON,MA 02111

[2] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT SURG,BOSTON,MA 02115

来源：

LANCET | 1991年 / 338卷 / 8780期

关键词：

D O I：

10.1016/0140-6736(91)92725-H

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin-1 (IL-1) has been implicated in the pathogenesis of sepsis. IL-1-receptor antagonist (IL-1ra) is a naturally occurring inhibitor of IL-1 activity that competes with IL-1 for occupancy of cell-surface receptors but possesses no agonist activity. We induced endotoxaemia in 9 healthy human volunteers by injection of Escherichia coli endotoxin, and measured plasma concentrations of IL-1 and IL-1ra by radioimmunoassay during the next 24 h. Peak plasma concentrations of IL-1ra were about a hundred-fold greater than those of IL-1-beta. No IL-1 or IL-1ra were detectable in the plasma of 4 volunteers injected with saline. Our results suggest that the predominant natural response to endotoxin in man is the production of antagonist rather than agonist.

引用

页码：1423 / 1424

页数：2

共 11 条

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