EFFECTS OF INSULIN-LIKE GROWTH-FACTORS AND GROWTH-HORMONE ON THE INVITRO PROLIFERATION OF LYMPHOCYTES-T

被引：48

作者：

KOOIJMAN, R

WILLEMS, M

RIJKERS, GT

BRINKMAN, A

VANBUULOFFERS, SC

HEIJNEN, CJ

ZEGERS, BJM

机构：

[1] UNIV HOSP CHILDREN & YOUTH HET WILHELMINA KINDERZI, DEPT ENDOCRINOL, UTRECHT, NETHERLANDS

[2] ERASMUS UNIV, DEPT PATHOL 1, 3000 DR ROTTERDAM, NETHERLANDS

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 38卷 / 1-2期

关键词：

INSULIN-LIKE GROWTH FACTOR; GROWTH HORMONE; IGF-BINDING PROTEIN; PROLIFERATION; LYMPHOCYTE-T; MITOGEN;

D O I：

10.1016/0165-5728(92)90094-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The insulin-like growth factors I and II (IGF-I and IGF-II) promote proliferation and differentiation of many cell types. We report that recombinant IGF-I and IGF-II augment both the lectin- and anti-CD3-induced proliferation of human peripheral blood mononuclear cells (PBMC) at concentrations proportional to their binding affinities. IGF-I and IGF-II also augmented the lectin-induced proliferation of purified T lymphocytes. Effects of IGF-I were found in cultures of T cells vigorously depleted for monocytes and supplemented with saturating concentrations of interleukin-1. The latter results indicate that the effect of IGF-I on the proliferation of T lymphocytes can occur independent of monocytes or monocyte-derived factors.

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页码：95 / 104

页数：10

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