DIADENOSINE TETRAPHOSPHATE (AP4A) LEVELS IN HL-60 CELLS DURING DIFFERENTIATION INTO GRANULOCYTES AND MONOCYTES

被引：2

作者：

ANDERSSON, M

OREDSSON, SM

OLSSON, H

BERGSTRAND, H

机构：

[1] UNIV LUND, DEPT BIOCHEM, S-22100 LUND, SWEDEN

[2] AB DRACO, S-22100 LUND, SWEDEN

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1990年 / 22卷 / 06期

关键词：

D O I：

10.1016/0020-711X(90)90046-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. Diadenosine tetraphosphate (Ap4A) levels were determined in HL-60 cells differentiating into granulocytes or monocytes after treatment for 0-7 days with retinoic acid (RA) or 4-β-phorbol-12-myristate-13-acetate (PMA) respectively. 2. 2. The levels increased significantly compared to untreated control cells within 2 days and then declined again. 3. 3. In RA treated cells the levels finally decreased far below those of untreated HL-60 cells and became equal to those found in human granulocytes. 4. 4. PMA treatment had no effect on Ap4A levels in human granulocytes. 5. 5. A possible interaction between Ap4A and ADP-ribosyl transferase is discussed. © 1990.

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页码：665 / 668

页数：4

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