HIGHLY DIASTEREOSELECTIVE MICHAEL ADDITION-REACTIONS OF LITHIUM ENOLATES TO ETHYL 3-TRIFLUOROMETHYLACRYLATE

被引：33

作者：

YAMAZAKI, T

HAGA, J

KITAZUME, T

NAKAMURA, S

机构：

[1] TOKYO INST TECHNOL, DEPT BIOENGN, MIDORI KU, YOKOHAMA, KANAGAWA 227, JAPAN

[2] MITSUBISHI KASEI CORP, RES CTR, MIDORI KU, YOKOHAMA 227, JAPAN

来源：

CHEMISTRY LETTERS | 1991年 / 12期

关键词：

D O I：

10.1246/cl.1991.2171

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Michael addition reactions of lithium enolates derived from ketones, esters, and amides to ethyl 3-trifluoromethylacrylate were found to proceed smoothly in moderate to excellent chemical yields as well as with a high degree of diastereoselectivity at the newly formed carbon-carbon bond.

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页码：2171 / 2174

页数：4

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