STRUCTURAL ORGANIZATION OF THE GENES ENCODING HUMAN AND MURINE FK506-BINDING PROTEIN (FKBP)13 AND COMPARISON TO FKBP1

被引：17

作者：

HENDRICKSON, BA

ZHANG, W

CRAIG, RJ

JIN, YJ

BIERER, BE

BURAKOFF, S

DILELLA, AG

机构：

[1] CHILDRENS HOSP,DIV INFECT DIS,BOSTON,MA 02115

[2] SMITHKLINE BEECHAM PHARMACEUT CO,DEPT MOLEC GENET,KING OF PRUSSIA,PA 19406

[3] DANA FARBER CANC INST,DIV PEDIAT ONCOL,BOSTON,MA 02115

[4] BRIGHAM & WOMENS HOSP,DIV HEMATOL,BOSTON,MA 02115

[5] HARVARD UNIV,SCH MED,DEPT PEDIAT MED,BOSTON,MA 02115

来源：

GENE | 1993年 / 134卷 / 02期

基金：

美国国家卫生研究院;

关键词：

IMMUNOSUPPRESSANT; IMMUNOPHILIN; GENOMIC LIBRARY; RECOMBINANT DNA; RAPAMYCIN;

D O I：

10.1016/0378-1119(93)90106-D

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

FK506-binding protein (FKBP)12 and FKBP13 are members of a family of proteins which bind the immunosuppressant drugs, FK506 and rapamycin. FKBP12 and FKBP13 are encoded by distinct genes, designated FKBP1 and FKBP2, respectively. The structure of human FKBP1 was previously characterized. We now report the genomic structure of the human and murine FKBP2 genes. Comparison of FKBP1 and FKBP2 reveals significant homology and correlation of intron positions in the C-terminal region, suggesting that these genes may have evolved from a common ancestral gene.

引用

页码：271 / 275

页数：5

共 27 条

[1]

ALDAPE RA, 1992, J BIOL CHEM, V267, P16029

[2]

Ausubel FM., 1988, CURRENT PROTOCOLS MO

[3] 2 DISTINCT SIGNAL TRANSMISSION PATHWAYS IN LYMPHOCYTES-T ARE INHIBITED BY COMPLEXES FORMED BETWEEN AN IMMUNOPHILIN AND EITHER FK506 OR RAPAMYCIN [J].