CONFORMATION-ACTIVITY RELATIONSHIP STUDY OF 5-HT3 RECEPTOR ANTAGONISTS AND A DEFINITION OF A MODEL FOR THIS RECEPTOR-SITE

被引：115

作者：

HIBERT, MF

HOFFMANN, R

MILLER, RC

CARR, AA

机构：

[1] Merrell Dow Research Institute, 67084 Strasbourg Cedex, 16, rue d'Ankara

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 33卷 / 06期

关键词：

D O I：

10.1021/jm00168a011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A conformation-activity relationship study of 5-HT3 receptor antagonists was used to define a pharmacophore and receptor map to qualitatively account for their activity. The design and synthesis of specific keto-amino-indole derivatives that are potent 5-HT3 receptor antagonists gave some support to the model. © 1990, American Chemical Society. All rights reserved.

引用

页码：1594 / 1600

页数：7

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