ANTI-CD4 ANTIBODIES ARE ASSOCIATED WITH HIV-1 SEROCONVERSION AND MAYBE DETECTABLE BEFORE ANTI-HIV-1 ANTIBODIES

被引：14

作者：

KEISER, P

KEAY, S

WASSERMAN, S

WECKSLER, W

机构：

[1] UNIV MARYLAND,SCH MED,DIV INFECT DIS,10 S PINE ST,MSTF RM 901,BALTIMORE,MD 21201

[2] DEPT VET AFFAIRS MED CTR,BALTIMORE,MD 21218

[3] UNIV MARYLAND,SCH MED,CTR VACCINE DEV,BALTIMORE,MD 21201

[4] SMITHKLINE BEECHAM,CLIN LABS,VAN NUYS,CA 91405

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1992年 / 8卷 / 11期

关键词：

D O I：

10.1089/aid.1992.8.1919

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the sera from 14 HIV-1 seroconverters for the presence of autoantibodies against CD4. Anti-CD4 antibodies were detected in the serum of 11 of 13 HIV-1-infected persons at the time of HIV-1 seroconversion. In 6 of 14 persons from whom a serum was obtained prior to HIV-1 seroconversion, anti-CD4 antibodies were found 90 to 540 days before antibodies to HIV-1 were detectable. In comparison, anti-CD4 antibodies were present in only 7 serum samples from 62 HIV-1 seronegative individuals, including 50 from a seronegative homosexual male cohort. These results suggest that anti-CD4 antibodies are generated in response to early HIV-1 infection and possibly could be used as a marker for HIV-1 infection in some infected persons who are seronegative for HIV-1.

引用

页码：1919 / 1927

页数：9

共 27 条

[1] PERTURBATION OF THE T4 MOLECULE TRANSMITS A NEGATIVE SIGNAL TO T-CELLS [J].