EXCRETION AND BIOTRANSFORMATION OF ASTEMIZOLE IN RATS, GUINEA-PIGS, DOGS, AND MAN

被引：22

作者：

MEULDERMANS, W ^{[1
]}

HENDRICKX, J ^{[1
]}

LAUWERS, W ^{[1
]}

HURKMANS, R ^{[1
]}

SWYSEN, E ^{[1
]}

HEYKANTS, J ^{[1
]}

机构：

[1] JANSSEN PHARMACEUT,RES LABS,DEPT ANALYT RES,B-2340 BEERSE,BELGIUM

来源：

DRUG DEVELOPMENT RESEARCH | 1986年 / 8卷 / 1-4期

关键词：

D O I：

10.1002/ddr.430080106

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：37 / 51

页数：15

共 7 条

[1]

MEULDERMANS W, 1983, ARZNEIMITTEL-FORSCH, V33-2, P1142

[2]

MEULDERMANS W, 1981, European Journal of Drug Metabolism and Pharmacokinetics, V6, P49

[3] PHARMACOKINETICS AND TISSUE DISTRIBUTION OF ASTEMIZOLE IN THE DOG [J].

MICHIELS, M ;

VANPEER, A ;

WOESTENBORGHS, R ;

HEYKANTS, J .

DRUG DEVELOPMENT RESEARCH, 1986, 8 (1-4) :53-62

[4] ASTEMIZOLE - A REVIEW OF ITS PHARMACODYNAMIC PROPERTIES AND THERAPEUTIC EFFICACY [J].

RICHARDS, DM ;

BROGDEN, RN ;

HEEL, RC ;

SPEIGHT, TM ;

AVERY, GS .

DRUGS, 1984, 28 (01) :38-61

[5]

Smith RL, 1973, EXCRETORY FUNCTION B, P76

[6]

TESTA B, 1976, DRUG METABOLISM CHEM, P202

[7] SYNTHESIS OF H-3-LABELED AND C-14-LABELED ASTEMIZOLE (R-43-512) [J].

THIJSSEN, JBA ;

KNAEPS, AG ;

HEYKANTS, JJP .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1983, 20 (07) :861-868

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