CLONING OF THE MOUSE INSULIN-RECEPTOR SUBSTRATE-1 (IRS-1) GENE AND COMPLETE SEQUENCE OF MOUSE IRS-1

被引：28
作者：
ARAKI, E
HAAG, BL
KAHN, CR
机构：
[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,DEPT MED,DIV RES,BOSTON,MA 02215
[2] HARVARD UNIV,SCH MED,JOSLIN DIABET CTR,BOSTON,MA 02215
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1994年 / 1221卷 / 03期
关键词：
IRS-1; CDNA; (MOUSE);
D O I：
10.1016/0167-4889(94)90261-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mouse IRS-1 gene has been cloned and its structure determined. Mouse IRS-1 differs from rat by the absence of the potential C-terminal nucleotide binding site. Otherwise, the predicted IRS-1 protein is highly conserved between mouse, rat and humans, especially in the possible phosphorylation sites. The highly conserved nature of IRS-1 suggests the importance of these domains in the function of IRS-1 or its association with other proteins.
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收藏
页码：353 / 356
页数：4
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