SYNTHESIS OF 2-CHLORO-4,6-DI(HETEROARYL)PYRIMIDINES

被引：33

作者：

STREKOWSKI, L

HARDEN, DB

GRUBB, WB

PATTERSON, SE

CZARNY, A

MOKROSZ, MJ

CEGLA, MT

WYDRA, RL

机构：

[1] Department of Chemistry, Georgia State University, Atlanta, Georgia

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 05期

关键词：

D O I：

10.1002/jhet.5570270539

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical method for the preparation of 2‐chloro‐4,6‐di(heteroaryl)pyrimidines and their 5‐methyl homologues from readily available 2‐chloropyrimidine and 2‐chloro‐5‐methylpyrimidine, respectively, is described. The method is based on the addition reactions of heteroaryllithium reagents with chloropyrimidines followed by dehydrogenation of the resultant substituted dihydropyrimidines. The use of 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone as the dehydrogenation agent gives the best results. Side reactions in the addition step are discussed. Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：1393 / 1400

页数：8