MODIFICATION OF DNA BY BILE-ACIDS - A POSSIBLE FACTOR IN THE ETIOLOGY OF COLON CANCER

被引：28

作者：

CHEAH, PY ^{[1
]}

BERNSTEIN, H ^{[1
]}

机构：

[1] UNIV ARIZONA,COMM GENET,TUCSON,AZ 85724

来源：

CANCER LETTERS | 1990年 / 49卷 / 03期

关键词：

bile acids; chenodeoxycholic acid; colon cancer; deoxycholic acid; DNA-damage; M13; transfection;

D O I：

10.1016/0304-3835(90)90160-Y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bile acids have been implicated as promoters and cocarcinogens in the etiology of colon cancer and as comutagens and mutagens in bacteria. These observations suggest the hypothesis that bile acids may interact directly with DNA. We treated the single stranded circular DNA of phage M13 with bile acids and found that the transfection efficiency of this DNA declined up to a 1000-fold. This result suggests that bile acids can damage DNA and thus may play an important role in the etiology of colon cancer. © 1990.

引用

页码：207 / 210

页数：4

共 24 条

[1]

CHEAH PY, 1990, IN PRESS NUTR CANCER

[2]

COHEN BI, 1986, DIETARY FIBER BASIC, P487

[3]

Domellof L, 1982, Nutr Cancer, V4, P120, DOI 10.1080/01635588209513747

[4]

HAENSZEL W, 1971, CANCER, V28, P14, DOI 10.1002/1097-0142(197107)28:1<14::AID-CNCR2820280105>3.0.CO