RAPID METHOD FOR THE DETECTION AND QUANTIFICATION OF N-NITROSODIBUTYLAMINE IN RUBBER PRODUCTS

被引：9
作者：
ZWICKENPFLUG, W
RICHTER, E
机构：
[1] Ludwig-Maximilians-Univ Muenchen, Munich, West Ger, Ludwig-Maximilians-Univ Muenchen, Munich, West Ger
来源：
JOURNAL OF CHROMATOGRAPHIC SCIENCE | 1987年 / 25卷 / 11期
关键词：
CHROMATOGRAPHIC ANALYSIS - Gas - RUBBER - Chromatographic Analysis;
D O I：
10.1093/chromsci/25.11.506
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A rapid method for the detection and quantification of N-nitrosodibutylamine (NDBA) migrating from rubber products into a neutral buffer solution is described. The extraction, clean up, and concentration is done by a one-step procedure using C//1//6 cartridges. NDBA in the ppb range is identified and quantitated by gas chromatography (GC) with a thermal energy analyzer (TEA) as detector.
引用
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页码：506 / 509
页数：4
相关论文
共 15 条
[1]  
BILLEDEAU SM, 1986, J ASSOC OFF ANA CHEM, V69, P31
[2]   ORGANOTROPE CARCINOGENE WIRKUNGEN BEI 65 VERSCHIEDENEN N-NITROSO-VERBINDUNGEN AN BD-RATTEN [J].
DRUCKREY, H ;
PREUSSMA.R ;
IVANKOVI.S ;
SCHMAHL, D ;
AFKHAM, J ;
BLUM, G ;
MENNEL, HD ;
MULLER, M ;
PETROPOU.P ;
SCHNEIDE.H .
ZEITSCHRIFT FUR KREBSFORSCHUNG, 1967, 69 (02) :103-&
[3]   PRINCIPLE OF OPERATION OF THERMAL ENERGY ANALYZER FOR TRACE ANALYSIS OF VOLATILE AND NONVOLATILE N-NITROSO COMPOUNDS [J].
FINE, DH ;
LIEB, D ;
RUFEH, F .
JOURNAL OF CHROMATOGRAPHY, 1975, 107 (02) :351-357
[4]   REDUCTION IN LEVELS OF VOLATILE N-NITROSAMINES IN RUBBER NIPPLES FOR BABIES BOTTLES [J].
HAVERY, DC ;
PERFETTI, GA ;
CANAS, BJ ;
FAZIO, T .
FOOD AND CHEMICAL TOXICOLOGY, 1985, 23 (11) :991-993
[5]  
HAVERY DC, 1983, J ASSOC OFF ANA CHEM, V66, P1500
[6]   FORMATION OF N-NITROSO COMPOUNDS - CHEMISTRY, KINETICS, AND INVIVO OCCURRENCE [J].
MIRVISH, SS .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1975, 31 (03) :325-351
[7]   N-NITROSAMINES AND NITROSATABLE COMPOUNDS IN RUBBER NIPPLES AND PACIFIERS [J].
OSTERDAHL, BG .
FOOD AND CHEMICAL TOXICOLOGY, 1983, 21 (06) :755-757
[8]   MASS-SPECTROMETRY OF N-NITROSAMINES [J].
RAINEY, WT ;
CHRISTIE, WH ;
LIJINSKY, W .
BIOMEDICAL MASS SPECTROMETRY, 1978, 5 (06) :395-408
[9]   INTESTINAL METABOLISM OF NITROSAMINES .1. TRANSPORT AND METABOLISM OF 6 NITROSAMINES IN ISOLATED PERFUSED RAT SMALL INTESTINAL SEGMENTS [J].
RICHTER, E ;
RICHTERCOOBERG, U ;
FENG, X ;
SCHULZE, J ;
WIESSLER, M .
CARCINOGENESIS, 1986, 7 (07) :1207-1213
[10]  
RICHTER E, 1987, IARC SCI PUBL, V84, P156
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