CHRONIC ETHANOL ADMINISTRATION DECREASES BRAIN-DERIVED NEUROTROPHIC FACTOR GENE-EXPRESSION IN THE RAT HIPPOCAMPUS

被引：2

作者：

MACLENNAN, AJ ^{[1
]}

LEE, N ^{[1
]}

WALKER, DW ^{[1
]}

机构：

[1] VET ADM MED CTR,GAINESVILLE,FL 32610

来源：

NEUROSCIENCE LETTERS | 1995年 / 197卷 / 02期

关键词：

BRAIN-DERIVED NEUROTROPHIC FACTOR; BASIC FIBROBLAST GROWTH FACTOR; NEUROTROPHIN-3; HIPPOCAMPUS; ETHANOL; MESSENGER-RNA;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have previously demonstrated that chronic ethanol consumption decreases neurotrophic activity in hippocampal extracts, as assessed by a chick dorsal root ganglia bioassay, but has no effect on hippocampal NGF mRNA or NGF protein levels, We presently report that hippocampal mRNAs encoding neurotrophin-3 and basic fibroblast growth factor are also unaffected. However, in contrast, brain-derived neurotrophic factor mRNA is reliably decreased, thereby suggesting that ethanol-induced damage of the septohippocampal system may at least partially result from an ethanol-induced decrease in hippocampal brain-derived neurotrophic factor expression.

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页码：105 / 108

页数：4

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