CARDIOPULMONARY EFFECTS OF MEDETOMIDINE-MIDAZOLAM AND MEDETOMIDINE-MIDAZOLAM-ATIPAMEZOLE IN LABORATORY PIGS

The cardiopulmonary effects of medetomidine (40 mug/kg)-midazolam (0.2 mg/kg) and medetomidine (40 mug/kg)-midazolam (0.2 mg/kg)-atipamezole (160 mug/kg) were evaluated in laboratory pigs. The intramuscular administration of medetomidine-midazolam caused a pressor response, characterized by a rapid increase in arterial and pulmonary arterial pressure mediated mainly through systemic and pulmonary vasoconstriction. These pressures decreased after reaching a peak 5 to 10 min after the administration of sedatives, but maintained higher values than the base-line. However, all these changes caused by medetomidine-midazolam were within the physiological fluctuation. In addition, this combination did not induce bradycardia, subsequent hypotension or a significant decrease in cardiac output, which were generally observed with alpha2-adrenoceptor agonists, and caused fewer changes in the respiratory system. The administration of atipamezole resulted in a marked transient decrease in vascular resistance, and caused a decrease in blood pressure and increases in cardiac output and heart rate. However, these changes were relatively small and sustained for a short time. Thus the combination of medetomidine-midazolam and atipamezole have minimal cardiopulmonary effects and might be used safely in laboratory pigs.