PROTECTION OF HYDROXY-GROUPS BY SILYLATION - USE IN PEPTIDE-SYNTHESIS AND AS LIPOPHILICITY MODIFIERS FOR PEPTIDES

被引：61

作者：

DAVIES, JS

HIGGINBOTHAM, CL

TREMEER, EJ

BROWN, C

TREADGOLD, RC

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,ANALYT SCI,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND

[2] DOW CORNING LTD,BARRY CF6 7YL,S GLAM,WALES

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 22期

关键词：

D O I：

10.1039/p19920003043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A survey of a series of organosilyl derivatives of serine and tyrosine has shown that they have a satisfactory stability profile for use in peptide synthesis. Only when alkaline conditions were used did side-reactions appear. A range of stability profiles have been determined from a study of organosilyl derivatised dipeptides under different conditions, giving t1/2-values for hydrolysis ranging from 41 to 465 min in acid conditions, yet giving long-term stability at pH-values near to neutrality.

引用

页码：3043 / 3048

页数：6

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