IMIDAZO[2',3'/6,5]DIPYRIDO[3,2-B/2',3'-E]-1,4-DIAZEPINES - NONNUCLEOSIDE HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS WITH GREATER ENZYME AFFINITY THAN NEVIRAPINE

被引：34

作者：

TERRETT, NK

BOJANIC, D

MERSON, JR

STEPHENSON, PT

机构：

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80468-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The chemistry and SAR of a new series of imidazo[2',3':6,5]dipyrido[3,2-b:2',3'-e]-1,4-diazepines is described. These compounds show improved affinity for HIV-1 RTase and antiviral activity in vitro over nevirapine, which has undergone clinical trials.

引用

页码：1745 / 1750

页数：6

共 18 条

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