VINPOCETIN PROTECTS AGAINST EXCITOTOXIC CELL-DEATH IN PRIMARY CULTURES OF RAT CEREBRAL-CORTEX

被引：37

作者：

ERDO, SL ^{[1
]}

NINGSHENG, C ^{[1
]}

WOLFF, JR ^{[1
]}

KISS, B ^{[1
]}

机构：

[1] GEDEON RICHTER CHEM WORKS LTD,CHEM WORKS,PHARMACOL RES CTR,DIV BIOCHEM,H-1475 BUDAPEST,HUNGARY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 187卷 / 03期

关键词：

Cerebrocortical cultures; Excitotoxic cell death; Glutamate; Kainate; NMDA (N-methyl-D-aspartate); Quisqualate; Vinpocetin;

D O I：

10.1016/0014-2999(90)90386-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The protective effect of vinpocetin, a drug clinically useful in brain hypoxia/ischemia, was examined in vitro on cerebrocortical cultures treated with glutamate and related excitotoxins. The extent of cell death was quantified by measuring lactic dehydrogenase activity released from damaged cells into the culture medium. Vinpocetin partially protected the cortical cells against cell death induced by N-methyl-D-aspartate, quisqualate and kainate, indicating that the drug exerts a direct protective action on cerebrocortical cells bearing excitatory amino acid receptors. © 1990.

引用

页码：551 / 553

页数：3

共 10 条

[1]

BIRO K, 1976, ARZNEIMITTELFORSCH, V26, P1918

[2] GROWTH OF A RAT NEUROBLASTOMA CELL LINE IN SERUM-FREE SUPPLEMENTED MEDIUM [J].

BOTTENSTEIN, JE ;

SATO, GH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (01) :514-517

[3] GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM [J].

CHOI, DW .

NEURON, 1988, 1 (08) :623-634

[4] GABA DOES NOT PROTECT CEREBROCORTICAL CULTURES AGAINST EXCITOTOXIC CELL-DEATH [J].

ERDO, SL ;

MICHLER, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 182 (01) :203-206

[5] PROTECTIVE EFFECT OF VINPOCETINE ON EXPERIMENTAL BRAIN ISCHEMIA [J].

KAKIHANA, M ;

SUNO, M ;

SHIBOTA, M ;

HAMAJO, K ;

NAGAOKA, A .

FOLIA PHARMACOLOGICA JAPONICA, 1982, 80 (03) :225-229

[6]

KING GA, 1987, ARCH INT PHARMACOD T, V286, P299

[7]

LORINCZ C, 1976, ARZNEIMITTEL-FORSCH, V26, P1907

[8]

OTOMO E, 1985, CURR THER RES CLIN E, V37, P811

[9] VINPOCETINE PREVENTS ISCHEMIC CELL-DAMAGE IN RAT HIPPOCAMPUS [J].

SAUER, D ;

RISCHKE, R ;

BECK, T ;

ROSSBERG, C ;

MENNEL, HD ;

BIELENBERG, GW ;

KRIEGLSTEIN, J .

LIFE SCIENCES, 1988, 43 (21) :1733-1739

[10]

WROBLEWSKI F, 1955, P SOC EXP BIOL MED, V90, P210

← 1 →