PSEUDOMONAS-AERUGINOSA FLAGELLAR ANTIBODIES IN SERUM, SALIVA AND SPUTUM FROM PATIENTS WITH CYSTIC-FIBROSIS

被引：4

作者：

NELSON, JW

GOVAN, JRW

BARCLAY, GR

机构：

[1] Department of Medical Microbiology, University of Edinburgh Medical School, Edinburgh, EH8 9AG Scotland, Teviot Place

[2] Regional Blood Transfusion Centre, Royal Infirmary, Edinburgh, Scotland

[3] Department of Transfusion Medicine, Royal Infirmary, Edinburgh, Scotland

来源：

SERODIAGNOSIS AND IMMUNOTHERAPY IN INFECTIOUS DISEASE | 1990年 / 4卷 / 05期

关键词：

PSEUDOMONAS-AERUGINOSA; FLAGELLA; ANTIBODY; CYSTIC FIBROSIS;

D O I：

10.1016/0888-0786(90)90025-J

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Flagellar preparations from Pseudomonas aeruginosa strains were characterized and used in ELISA and immunoblot studies to detect anti-P. aeruginosa flagellar antibodies in sera, saliva and sputum from patients with cystic fibrosis (CF). Serum antiflagellar IgG antibodies were detected, particularly in those CF patients intermittently or chronically colonized by P. aeruginosa. Antibodies to both type-a and -b flagella were detected; however, in some patients a pronounced antibody response to only one of the flagellar types was evident. Raised levels of anti-flagellar antibodies in intermittently and non-P. aeruginosa colonized patients may represent an early antibody response to P. aeruginosa colonization of the CF respiratory tract and implicate instigation of early anti-pseudomonal antibiotic therapy. © 1990.

引用

页码：351 / 361

页数：11

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