The 24-hour intraocular pressure control by tafluprost/timolol fixed combination after switching from the concomitant use of tafluprost and timolol gel-forming solution, in patients with primary open-angle glaucoma

被引：4

作者：

Nakamoto, Kenji ^{[1
]}

Takeshi, Masahiko ^{[2
]}

Hiraoka, Toshihiko ^{[2
,3
]}

Eguchi, Mayuko ^{[2
,4
]}

Nakano, Yuichiro ^{[1
,2
]}

Otsuka, Naomi ^{[5
]}

Hizaki, Hiroko ^{[5
]}

Akai, Hiromi ^{[5
]}

Hashimoto, Masayo ^{[5
]}

机构：

[1] Nippon Med Sch, Dept Ophthalmol, Tokyo, Japan

[2] Shinanozaka Clin, Tokyo, Japan

[3] Hiraoka Eye Clin, Saitama, Japan

[4] Musashiurawa Eye Clin, Saitama, Japan

[5] Santen Pharmaceut Co Ltd, Global R&D, Japan Med Affairs, Osaka, Japan

来源：

CLINICAL OPHTHALMOLOGY | 2018年 / 12卷

关键词：

intraocular pressure; tafluprost; circadian IOP; 24-hour IOP; timolol gel;

D O I：

10.2147/OPTH.S152507

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Objective: The aim of this study was to evaluate the 24-hour intraocular pressure (IOP)-control effect of the tafluprost/timolol fixed combination (TAF/TIM-FC) in patients with primary open-angle glaucoma after they switched from the concomitant use of tafluprost and timolol gel-forming solution. Patients and methods: Twenty patients with primary open-angle glaucoma (12 male and 8 female; mean +/- SD age, 57.0 +/- 7.1 years) were included in this study. The patients were treated for 8 weeks with the concomitant administration of tafluprost and timolol gel-forming solution (evening dosing). At the end of this period, the patients underwent 24-hour IOP monitoring (measured at 21:00, 01:00, 05:00, 09:00, 13:00 and 17:00). IOP was measured with Goldmann applanation tonometer (GAT) and Icare PRO at sitting position at all timepoints and additionally, at supine position with Icare PRO tonometer at 01:00 and 05:00. The patients were then all switched to TAF/TIM-FC treatment (evening dosing). After 8 weeks, the 24-hour IOP monitoring was repeated. Results: Nineteen patients completed the study. The mean 24-hour IOPs in the concomitant and TAF/TIM-FC phases were 13.8 +/- 2.7 vs 13.3 +/- 2.8 mmHg (P=0.0033) with the GAT in the sitting position and 13.96 +/- 2.56 vs 13.48 +/- 2.56 mmHg (P=0.0120) with the Icare PRO in habitual positions. In comparison with the concomitant phase, significantly lower IOP was observed for the TAF/TIM-FC phase at 21:00 and 01:00 with the GAT and at 01:00 with the Icare PRO. In addition, the maximum IOP and fluctuations in IOP in habitual positions were lower for the TAF/TIM-FC phase than for the concomitant phase. Conclusion: TAF/TIM-FC showed a stable 24-hour IOP-lowering effect and was equally or more effective than the concomitant use of tafluprost and timolol gel, both when sitting and when in habitual positions.

引用

页码：359 / 367

页数：9

共 25 条

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