NBQX, AN IMPROVED NON-NMDA ANTAGONIST STUDIED IN RETINAL GANGLION-CELLS

被引：39

作者：

YU, WF ^{[1
]}

MILLER, RF ^{[1
]}

机构：

[1] UNIV MINNESOTA,DEPT PHYSIOL,6-255 MILLARD HALL,435 DELAWARE ST SE,MINNEAPOLIS,MN 55455

来源：

BRAIN RESEARCH | 1995年 / 692卷 / 1-2期

关键词：

NBQX; CNQX; RETINAL GANGLION CELL; NMDA AND NON-NMDA RECEPTOR;

D O I：

10.1016/0006-8993(95)00665-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The quinoxaline derivative, 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo (F) quinoxaline (NBQX), significantly reduced the currents evoked by exogenous application of quisqualate (QQ), kainate (KA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) when applied to ganglion cells, using whole-cell recording in a slice preparation of the tiger salamander retina. A comparison between NBQX and CNQX indicates that NBQX is more effective in blocking AMPA receptors. Also, at up to 10 mu M, NBQX has no effect on NMDA-induced currents. Thus at this concentration, NBQX shows no affinity for the glycine binding site of NMDA receptors. For this reason, NBQX is preferred over CNQX for a more effective and selective antagonism toward non-NMDA receptors.

引用

页码：190 / 194

页数：5

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