The relevance of glucocorticoid receptor in early stress

被引：0
|
作者：
Rodriguez Fernandez, Jorge Mario [1 ]
Garcia Acero, Mary [2 ]
机构：
[1] Univ Javeriana, Hosp Univ San Ignacio Pontificia, Fac Med, Grp Neurociencias, Bogota, Colombia
[2] Pontificia Univ Javeriana, Bogota, Colombia
来源：
UNIVERSITAS MEDICA | 2010年 / 51卷 / 04期
关键词：
stress; depression; system; glucocorticoid; development;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Previous studies have shown how Hypothalamic-Pituitary-adrenal Axis dysfunction is related to early life stress; several works show that Hypothalamic-Pituitary-adrenal Axishyperactivity increases production of ACTH and glucocorticoids, indicating a pathophysiological key factor in stress related diseases like depression. This review will discuss results of some epigenetical studies linking early life stress, decreased production of the glucocorticoid receptor and Hypothalamic-Pituitary-adrenal Axis hyperactivity. We conclude how early life stress modulates the expression of the glucocorticoid receptor affecting the development of several brain structures involved in the stress response.
引用
收藏
页码：385 / 391
页数：7
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