SYNTHESIS OF BETA-LACTAMS OF HIGH ENANTIOMERIC PURITY BY CHIRAL LIGAND ACCELERATED OSMYLATION OF RACEMIC 4-(2-STYRYL)-AZETIDIN-2-ONES

被引：3
|
作者：
ANNUNZIATA, R
BENAGLIA, M
CINQUINI, M
COZZI, F
PONZINI, F
机构：
[1] UNIV MILAN,CTR CNR,VIA GOLGI 19,I-20133 MILAN,ITALY
[2] UNIV MILAN,DIPARTIMENTO CHIM ORGAN & IND,I-20133 MILAN,ITALY
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期
关键词：
D O I：
10.1016/S0960-894X(01)80963-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The catalytic osmylation of a series of 4-(2-styryl)-azetidin-2-ones carried out in the presence of dihydroquinidine-p-chlorobenzoate opens access to synthetically useful precursors of beta-lactam antibiotics of high enantiomeric purity (ee up to 97%).
引用
收藏
页码：2397 / 2402
页数：6
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