IMMUNE EFFECTOR MECHANISMS IN HEART-TRANSPLANT REJECTION

被引：12
作者：
BINAH, O [1 ]
机构：
[1] STANFORD SCH MED,FALK CARDIOVASC RES CTR,DEPT CARDIOVASC MED,STANFORD,CA
来源：
CARDIOVASCULAR RESEARCH | 1994年 / 28卷 / 12期
关键词：
HEART TRANSPLANT REJECTION; MYOCARDITIS AND CARDIOMYOPATHY; CYTOTOXIC T LYMPHOCYTES; VENTRICULAR MYOCYTES; LYTIC GRANULES; PERFORIN;
D O I：
10.1093/cvr/28.12.1748
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
It is well established that immunological mechanisms are responsible for the pathophysiology of several heart diseases, some contributing significantly to morbidity and mortality worldwide. Of the multiple cellular and humoral components participating in the overall immune response in heart diseases, this article mainly deals with cellular immunity mediated by cytotoxic T lymphocytes (CTL). Three important heart diseases have been associated with CTL induced myocardial damage: (1) heart transplant rejection; (2) myocarditis and dilated cardiomyopathy; (3) Chagas heart disease.
引用
收藏
页码：1748 / 1757
页数：10
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