INVOLVEMENT OF NITRIC-OXIDE FORMATION IN THE ACTION OF LOSARTAN (DUP-753) - EFFECTS IN AN INHIBITORY AVOIDANCE MODEL

被引：12

作者：

HOCK, FJ

机构：

[1] Pharmaceutical Division, General Pharma Research, Pharmacological Screening, D-65926 Frankfurt/M

来源：

BEHAVIOURAL BRAIN RESEARCH | 1994年 / 61卷 / 02期

关键词：

NITRIC OXIDE; LOSARTAN; N-G-NITRO-L-ARGININE; MEMORY;

D O I：

10.1016/0166-4328(94)90156-2

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The potent and selective orally active ANG II receptor antagonist losartan (DuP 753) enhanced the retentions in an inhibitory (passive) avoidance test after scopolamine amnesia. In addition, the influence of the specific NO-synthase inhibitor N-G-nitro-L-arginine (L-NNA) in combination with losartan was tested. L-NNA itself shows no effect. The combination of losartan with L-NNA did not produce any prolongation of step-through latencies.

引用

页码：163 / 167

页数：5

共 37 条

[1]

Barnes N M, 1990, Neuroreport, V1, P239, DOI 10.1097/00001756-199011000-00017

[2] MEMORY DEFICITS IN AGED CEBUS MONKEYS AND FACILITATION WITH CENTRAL CHOLINOMIMETICS [J].