RECENT ADVANCES IN THE ELECTROPHYSIOLOGICAL CHARACTERIZATION OF 5-HT3 RECEPTORS

被引：115

作者：

PETERS, JA

MALONE, HM

LAMBERT, JJ

机构：

[1] Ninewells Hospital, Medical School, The University, Dundee

[2] Ninewells Hospital, Medical School, The University, Dundee

[3] Ninewells Hospital, Medical School, The University, Dundee

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1992年 / 13卷 / 10期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0165-6147(92)90119-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

5-HT3 receptors are ligand-gated, cation-selective ion channels, mediating membrane depolarization and neuronal excitation. Established and potential therapeutic applications of selective 5-HT3 receptor antagonists, coupled with the localization of this receptor subtype within discrete areas of the CNS, have resulted in an intensification of research in this area. In this review, Jeremy Lambert and colleagues summarize recent developments in the electrophysiological characterization of 5-HT3 receptors, and comment upon the unresolved issue of 5-HT3 receptor heterogeneity.

引用

页码：391 / 397

页数：7

共 49 条

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