THE IMMUNE-RESPONSE TO ANTIIDIOTYPE ANTIBODIES BEARING AN INTERNAL IMAGE EPITOPE OF TETANUS TOXIN TOXOID .2. COMPARISON OF THE PRIMARY HUMORAL IMMUNE-RESPONSE TO XENOGENEIC AB2-BETA-1 AND AB2-BETA-2 INTERNAL IMAGE ANTIIDIOTYPE ANTIBODIES

被引：1

作者：

POSKITT, DC

TURNBULL, S

MACDONALD, L

JEANFRANCOIS, MJB

YASMEEN, D

机构：

[1] Commonwealth Serum Laboratories, Research and Development Division, Melbourne

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1991年 / 95卷 / 2-3期

关键词：

D O I：

10.1159/000235415

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Mouse monoclonal (Ab1) anti-tetanus toxin/toxoid antibodies were used to raise Ab2-beta (tetanus toxin/toxoid internal image bearing) anti-idiotype antibodies in rabbits. Those rabbit serum antibodies (Ab2-beta) that did not bind to mouse serum proteins on an affinity column gave rise to an Ab3 anti-tetanus toxin/toxoid antibody response in mice. Rabbit serum antibodies that did bind to the affinity column, when eluted and used to inoculate mice also gave rise to an Ab3 anti-tetanus toxin/toxoid antibody response. It is suggested that one population of rabbit Ab2-beta anti-idiotype antibodies (unbound fraction) bears a partial or complete internal image of a tetanus epitope (Ab2-beta-1) while others (bound fraction) bear a complete or partial mirror image of a mouse immunoglobulin epitope as well (Ab2-beta-2).

引用

页码：122 / 127

页数：6

共 9 条

[1] THE IMMUNE-RESPONSE TO ANTIIDIOTYPE ANTIBODIES BEARING AN INTERNAL IMAGE EPITOPE OF TETANUS TOXIN TOXOID .1. INDUCTION OF THE HUMORAL IMMUNE-RESPONSE
POSKITT, DC
TURNBULL, S
MACDONALD, L
JEANFRANCOIS, MJB
YASMEEN, D
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1991, 95 (2-3): : 109 - 121
[2] INTERNAL IMAGE (AB2-BETA) ANTIIDIOTYPE VACCINES - THEORETICAL AND PRACTICAL ASPECTS
POSKITT, DC
JEANFRANCOIS, MJB
TURNBULL, S
MACDONALD, L
YASMEEN, D
VACCINE, 1991, 9 (11) : 792 - 796
[3] THE IMMUNE-RESPONSE AGAINST ANTI-IDIOTOPE ANTIBODIES .2. THE INDUCTION OF ANTIBODIES BEARING THE TARGET IDIOTOPE (AB3-BETA) DEPENDS ON THE FREQUENCY OF THE CORRESPONDING B-CELLS
TESCH, H
TAKEMORI, T
RAJEWSKY, K
EUROPEAN JOURNAL OF IMMUNOLOGY, 1983, 13 (09) : 726 - 732
[4] REGULATION OF IMMUNE-RESPONSE .7. IN-VITRO IMMUNOSUPPRESSION BY F(AB')2 OR INTACT IGG ANTIBODIES
LEES, RK
SINCLAIR, NR
IMMUNOLOGY, 1973, 24 (04) : 735 - 750
[5] TUMOR-SPECIFIC IDIOTYPE VACCINES .2. ANALYSIS OF THE TUMOR-RELATED NETWORK RESPONSE INDUCED BY THE TUMOR AND BY INTERNAL IMAGE ANTIGENS (AB2-BETA)
RAYCHAUDHURI, S
SAEKI, Y
CHEN, JJ
IRIBE, H
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KOHLER, H
JOURNAL OF IMMUNOLOGY, 1987, 139 (01): : 271 - 278
[6] CHARACTERIZATION OF THE HUMORAL IMMUNE-RESPONSE IN PLASMODIUM-FALCIPARUM MALARIA .2. IGG SUBCLASS LEVELS OF ANTI-PLASMODIUM-FALCIPARUM ANTIBODIES IN DIFFERENT SERA
WAHLGREN, M
BERZINS, K
PERLMANN, P
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CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1983, 54 (01): : 135 - 142
[7] INDUCTION OF AN IMMUNE NETWORK CASCADE IN CANCER-PATIENTS TREATED WITH MONOCLONAL-ANTIBODIES (AB(1)) .2. IS INDUCTION OF ANTIIDIOTYPE REACTIVE T-CELLS (T-3) OF IMPORTANCE FOR TUMOR RESPONSE TO MAB THERAPY
FAGERBERG, J
FRODIN, JE
RAGNHAMMAR, P
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CANCER IMMUNOLOGY IMMUNOTHERAPY, 1994, 38 (03) : 149 - 159
[8] CHARACTERIZATION OF THE IMMUNE-RESPONSE TO A SECONDARY ENCEPHALITOGENIC EPITOPE OF BASIC-PROTEIN IN LEWIS RATS .2. BIASED T-CELL RECEPTOR V-BETA EXPRESSION PREDOMINATES IN SPINAL-CORD INFILTRATING T-CELLS
GOLD, DP
VAINIENE, M
CELNIK, B
WILEY, S
GIBBS, C
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VANDENBARK, AA
OFFNER, H
JOURNAL OF IMMUNOLOGY, 1992, 148 (06): : 1712 - 1717
[9] STUDIES ON IMMUNITY IN HYBRIDOMA-BEARING MICE .A. IMMUNE-RESPONSE TO ANTIGENS .2. INHIBITION OF PRODUCTION OF ANTI-DINITROPHENYL ANTIBODIES IN MICE WHICH HAVE REJECTED THE B53 ANTI-DINITROPHENYL-PRODUCING IGE HYBRIDOMA
YIN, JZ
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HIRANO, T
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INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1987, 83 (04): : 414 - 422

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