LYMPHOPENIA AND DECREASE IN THE TOTAL NUMBER OF CIRCULATING CD3+ AND CD4+ T-CELLS DURING LONG-TERM PUVA TREATMENT FOR PSORIASIS

被引:6
作者
BORRONI, G
ZACCONE, C
VIGNATI, G
FIETTA, A
GATTI, M
BRAZZELLI, V
RABBIOSI, G
机构
[1] UNIV PAVIA,IST RICOVERO & CURA CARATTERE SCI,CHAIR CHEMOTHERAPY,I-27100 PAVIA,ITALY
[2] UNIV PAVIA,IST RICOVERO & CURA CARATTERE SCI,INST DERMATOL,I-27100 PAVIA,ITALY
来源
DERMATOLOGICA | 1991年 / 183卷 / 01期
关键词
LYMPHOCYTE-T SUBSET IMPAIRMENT; LYMPHOPENIA; PERIPHERAL BLOOD; PUVA TREATMENT; PSORIASIS;
D O I
10.1159/000247624
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The relationship between high-dose PUVA treatment in psoriatic patients and peripheral T lymphocyte subsets (total number and percentage) has been studied. Of the two groups of patients considered, the first included 19 patients, all affected by chronic, progressively worsening psoriasis; they had never been previously treated by photochemotherapy. The second group included 13 psoriatic patients, who had received an average cumulative dose of 2,007.69 +/- 1,191.05 J/cm2. The 'long-term' PUVA-treated group was assessed while undergoing maintenance therapy. No significant differences were found between untreated patients and healthy controls for any of the parameters considered. A significant reduction (p < 0.05) in the total number of lymphocytes in long-term PUVA-treated patients both versus untreated patients and controls was found. Furthermore, long-term PUVA-treated patients showed a significant reduction (p < 0.05) in the percentage of lymphocytes as compared with controls. The reduction in the total number of CD3+ and CD4+ T cells was, moreover, significant (p < 0.05) as compared with untreated patients. The impairment of circulating CD3+ and CD4+ T cells (total number) was only on the borderline of statistical significance vis-a-vis controls. These findings suggest the usefulness of a careful assessment of circulating T lymphocyte subsets in patients who undergo long-term PUVA therapy.
引用
收藏
页码:10 / 14
页数:5
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