STUDIES OF ENZYME-MEDIATED REACTIONS .10. STEREOCHEMICAL COURSE OF THE DEHYDROGENATION OF STEREOSPECIFICALLY LABELED 1-AMINO-HEPTANES BY THE AMINE OXIDASE FROM RAT-LIVER MITOCHONDRIA (EC 1434)

被引：43

作者：

BATTERSBY, AR

BUCKLEY, DG

STAUNTON, J

WILLIAMS, PJ

机构：

[1] University Chemical Laboratory, Cambridge CB2 1EW, Lensfield Road

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1979年 / 10期

关键词：

D O I：

10.1039/p19790002550

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(1R)- and (1S)-[1-3H1]aminoheptanes are synthesised by a route which, in the deuterium series, allows direct correlation with the primary standard, monodeuteriosuccinic acid. The amines, thus of proven absolute stereochemistry, are then used as substrates for the monoamine oxidase from rat liver mitrochondria. The results prove that the (Re)-hydrogen (Scheme 1) is stereospecifically removed by the enzyme. Some anomalous values for retention of tritium found in these experiments lead to the studies described in the following paper.

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页码：2550 / 2558

页数：9

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