CHEMICAL AND BIOLOGICAL PROPERTIES OF RUBIGINONE, A COMPLEX OF NEW ANTIBIOTICS WITH VINCRISTINE-CYTOTOXICITY POTENTIATING ACTIVITY

被引：53

作者：

OKA, M

KAMEI, H

HAMAGISHI, Y

TOMITA, K

MIYAKI, T

KONISHI, M

OKI, T

机构：

[1] Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Tokyo 153, 2-9-3 Shimo-meguro, Meguro-ku

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 08期

关键词：

D O I：

10.7164/antibiotics.43.967

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel complex of isotetracenone (angucyclinone) group antibiotics was discovered from the cultured broth of Streptomyces griseorubiginosus No. Q144-2. The antibiotic consisted of six related factors, designated rubiginones A1, A2, B1, B2, C1 and C2. They significantly potentiated cytotoxicity of vincristine (VCR) against VCR-resistant P388 leukemia and Moser cells. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：967 / 976

页数：10

共 10 条

[1] METABOLIC PRODUCTS OF MICROORGANISMS .234. URDAMYCINS, NEW ANGUCYCLINE ANTIBIOTICS FROM STREPTOMYCES-FRADIAE .1. ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES [J].