DIFFERENTIAL-EFFECTS OF THE EXCITATORY AMINO-ACID ANTAGONISTS, 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE (CNQX) AND 3-((+/-)-2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID (CPP), ON SPINAL REFLEX ACTIVITY IN MICE

被引：43

作者：

TURSKI, L ^{[1
]}

BRESSLER, K ^{[1
]}

KLOCKGETHER, T ^{[1
]}

STEPHENS, DN ^{[1
]}

机构：

[1] UNIV TUBINGEN,DEPT NEUROL,W-7400 TUBINGEN 1,GERMANY

来源：

NEUROSCIENCE LETTERS | 1990年 / 113卷 / 01期

关键词：

Electromyogram; Monosynaptic reflex; Mouse; N-Methyl-d-aspartate antagonist; Polysynaptic reflex; Quisqualate antagonist;

D O I：

10.1016/0304-3940(90)90496-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intrathecal administration of the preferential quisqualate antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in anesthetized mice depressed Hoffmann (H)-reflexes, while flexor reflexes remained unaffected. The depressant effect of CNQX on H-reflexes was dose-dependent (range 0.1-10 nmol). The intrathecal administration of the selective N-methyl-d-aspartate (NMDA) antagonist 3-[(±)-2-carboxypiperazin-4-yl]-propyl-1-phosphonate (CPP) reduced flexor reflexes (range 10-100 nmol) and had no effect on H-reflexes. These results suggest that H-reflexes in mice are mediated by spinal non-NMDA receptors, while flexor reflexes involve NMDA receptors. © 1990.

引用

页码：66 / 71

页数：6

共 16 条

[1] DUAL-COMPONENT AMINO-ACID-MEDIATED SYNAPTIC POTENTIALS - EXCITATORY DRIVE FOR SWIMMING IN XENOPUS EMBRYOS [J].