REPAIR OF SUBLETHAL RADIATION-DAMAGE BY CAPILLARIES

被引：12

作者：

FIKE, JR

GILLETTE, EL

CLOW, DJ

机构：

[1] COLORADO STATE UNIV, DEPT RADIOL & RADIAT BIOL, COMPARAT ONCOL UNIT, FT COLLINS, CO 80523 USA

[2] COLORADO STATE UNIV, DEPT MATH, FT COLLINS, CO 80523 USA

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1979年 / 5卷 / 03期

关键词：

Canine corneas; Capillary endothelial cells; Incremental dose; Repair of sublethal damage; Time recovery;

D O I：

10.1016/0360-3016(79)91213-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neovascularization was induced surgically in normally avascular canine corneas to study the repair of sublethal damage in slowly proliferating capillary endothelial cells. Neovascularization was stimulated for 7 days after split dose treatments with 6Co γ-rays. Corneal tissue samples were evaluated by quantitative morphometric methods. A time recovery curve was drawn by plotting per cent capillary volume vs time between two equal doses. A typical Elkind type" of time recovery response was observed. A split dose response assay resulted in an incremental dose D2-D1 of 265 rad at the 1% capillary volume level. The results suggest a substantial repair capacity for capillary endothelial cells. © 1979."

引用

页码：339 / 342

页数：4