NEUROPROTECTION AFTER FOCAL CEREBRAL-ISCHEMIA IN HYPERGLYCEMIC AND DIABETIC RATS

被引：34
作者：
BOMONT, L
MACKENZIE, ET
机构：
[1] University of Caen, URA 1829 CNRS, Cyceron Research Center, 14074 Caen Cedex, Boulevard Henri Becquerel
来源：
NEUROSCIENCE LETTERS | 1995年 / 197卷 / 01期
关键词：
FOCAL CEREBRAL ISCHEMIA; INFARCT VOLUME; HYPERGLYCEMIA; DIABETES MELLITUS; INSULIN; DIZOCILPINE; FISCHER-344; RAT;
D O I：
10.1016/0304-3940(95)11899-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of acute hyperglycaemia and streptozotocin-induced diabetes on infarct size were measured 48 h after middle cerebral artery occlusion (MCAO) in Fischer 344 rats, Both hyperglycaemia (+46%) and diabetes (+68%) increased infarct volume when compared to normoglycaemic rats. Insulin-treated diabetic rats exhibited an infarct size similar to that observed in normoglycaemic rats. Neuroprotection has been difficult to demonstrate in pathological conditions that increase infarct volume such as chronic arterial hypertension, However, administration of the non-competitive NMDA antagonist, dizocilpine (MK-801), after MCAO, reduced the volume of ischaemic damage (by 33-48%) in all groups. The present findings indicate (a) that the detrimental effects of experimental diabetes on infarct volume are largely attributed to hyperglycaemia; and (b) dizocilpine was as neuroprotective in hyperglycaemia and diabetic conditions as in normoglycaemic rats.
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收藏
页码：53 / 56
页数：4
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