REPAIR AND RECOMBINATION - HOW TO MAKE ENDS MEET

被引：112

作者：

ROTH, DB

LINDAHL, T

GELLERT, M

机构：

[1] IMPERIAL CANC RES FUND,CLARE HALL LABS,S MIMMS EN6 3LD,HERTS,ENGLAND

[2] NIDDKD,MOLEC BIOL LAB,BETHESDA,MD 20892

来源：

CURRENT BIOLOGY | 1995年 / 5卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0960-9822(95)00101-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The repair of double-stranded breaks in DNA and the recombination of antibody gene V(D)J segments share a common pathway involving the Ku protein, which binds DNA ends, and its associated protein kinase.

引用

页码：496 / 499

页数：4

共 25 条

[1] NONHOMOLOGOUS DNA END JOINING OF SYNTHETIC HAIRPIN SUBSTRATES IN XENOPUS-LAEVIS EGG EXTRACTS [J].

BEYERT, N ;

REICHENBERGER, S ;

PETERS, M ;

HARTUNG, M ;

GOTTLICH, B ;

GOEDECKE, W ;

VIELMETTER, W ;

PFEIFFER, P .

NUCLEIC ACIDS RESEARCH, 1994, 22 (09) :1643-1650

[2] SCID MUTATION IN MICE CONFERS HYPERSENSITIVITY TO IONIZING-RADIATION AND A DEFICIENCY IN DNA DOUBLE-STRAND BREAK REPAIR [J].

BIEDERMANN, KA ;

SUN, JR ;

GIACCIA, AJ ;

TOSTO, LM ;

BROWN, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) :1394-1397

[3] DEFECTIVE DNA-DEPENDENT PROTEIN-KINASE ACTIVITY IS LINKED TO V(D)J RECOMBINATION AND DNA-REPAIR DEFECTS ASSOCIATED WITH THE MURINE SCID MUTATION [J].

BLUNT, T ;

FINNIE, NJ ;

TACCIOLI, GE ;

SMITH, GCM ;

DEMENGEOT, J ;

GOTTLIEB, TM ;

MIZUTA, R ;

VARGHESE, AJ ;

ALT, FW ;

JEGGO, PA ;

JACKSON, SP .

CELL, 1995, 80 (05) :813-823

[4] COMPLEMENTATION OF THE IONIZING-RADIATION SENSITIVITY, DNA END BINDING, AND V(D)J RECOMBINATION DEFECTS OF DOUBLE-STRAND BREAK REPAIR MUTANTS BY THE P86 KU AUTOANTIGEN [J].

BOUBNOV, NV ;

HALL, KT ;

WILLS, Z ;

LEE, SE ;

HE, DM ;

BENJAMIN, DM ;

PULASKI, CR ;

BAND, H ;

REEVES, W ;

HENDRICKSON, EA ;

WEAVER, DT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (03) :890-894

[5] AN INTERACTION BETWEEN THE MAMMALIAN DNA-REPAIR PROTEIN XRCC1 AND DNA LIGASE-III [J].

CALDECOTT, KW ;

MCKEOWN, CK ;

TUCKER, JD ;

LJUNGQUIST, S ;

THOMPSON, LH .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (01) :68-76

[6] DNA-DEPENDENT PROTEIN-KINASE ACTIVITY IS ABSENT IN XRS-6 CELLS - IMPLICATIONS FOR SITE-SPECIFIC RECOMBINATION AND DNA DOUBLE-STRAND BREAK REPAIR [J].

FINNIE, NJ ;

GOTTLIEB, TM ;

BLUNT, T ;

JEGGO, PA ;

JACKSON, SP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (01) :320-324

[7] THE SCID MUTATION IN MICE CAUSES A GENERAL DEFECT IN DNA-REPAIR [J].

FULOP, GM ;

PHILLIPS, RA .

NATURE, 1990, 347 (6292) :479-482

[8]

GETTS RC, 1994, J BIOL CHEM, V269, P15981

[9]

GIACCIA AJ, 1990, AM J HUM GENET, V47, P459

[10] A LINK BETWEEN DOUBLE-STRAND BREAK-RELATED REPAIR AND V(D)J RECOMBINATION - THE SCID MUTATION [J].

HENDRICKSON, EA ;

QIN, XQ ;

BUMP, EA ;

SCHATZ, DG ;

OETTINGER, M ;

WEAVER, DT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) :4061-4065

← 1 2 3 →