CIRCULATING INHIBITOR OF INTERLEUKIN-1 ACTIVITY IN PATIENTS WITH CHRONIC RENAL DISEASES

被引：4
作者：
RAMIC, Z
DIMKOVIC, N
DJUKANOVIC, L
LAZIC, M
STEPANOVIC, S
SIMIC, M
LUKIC, ML
机构：
[1] UNIV BELGRADE, SCH MED, INST MICROBIOL & IMMUNOL, DR SUBOTICA 1, YU-11000 BELGRADE, YUGOSLAVIA
[2] ZVEZDARA CLIN HOSP CTR, INST KIDNEY DIS, BELGRADE, YUGOSLAVIA
[3] UNIV BELGRADE, CTR CLIN, INST NEPHROL & UROL, BELGRADE, YUGOSLAVIA
来源：
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1992年 / 22卷 / 10期
关键词：
CHRONIC RENAL DISEASES; IMMUNOSUPPRESSION; INHIBITOR OF INTERLEUKIN-1 ACTIVITY;
D O I：
10.1111/j.1365-2362.1992.tb01430.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effects of sera derived from patients suffering from chronic renal diseases (endemic Balkan nephropathy, glomerulonephritis and pyelonephritis) on T cell proliferative response was studied. It was found that these sera contained factors which affect interleukin 1 (IL-1) dependent events in T cell proliferative response. The factors prevent costimulatory effects of IL-I on T cells but do not bind to IL-1, nor do they affect interleukin 2 (IL-2) dependent T cell proliferation. These findings indicate that immunosuppression observed in some kidney disorders may be partially due to serum immunoinhibitory factors affecting IL-1 activity.
引用
收藏
页码：681 / 686
页数：6
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