GENERATION OF PLASMACYTOMAS WITH THE CHROMOSOMAL TRANSLOCATION T(12-15) IN INTERLEUKIN-6 TRANSGENIC MICE

被引：218
作者：
SUEMATSU, S
MATSUSAKA, T
MATSUDA, T
OHNO, S
MIYAZAKI, J
YAMAMURA, K
HIRANO, T
KISHIMOTO, T
机构：
[1] OSAKA UNIV,SCH MED,BIOMED RES CTR,DIV MOLEC ONCOL,SUITA,OSAKA 565,JAPAN
[2] KANAZAWA UNIV,CANC RES INST,DEPT MOLEC IMMUNOL,KANAZAWA,ISHIKAWA 920,JAPAN
[3] KUMAMOTO UNIV,SCH MED,INST MED GENET,KUMAMOTO 862,JAPAN
[4] OSAKA UNIV,SCH MED,DEPT INTERNAL MED 3,FUKUSHIMA KU,OSAKA 553,JAPAN
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 01期
关键词：
BALB/C; GENETIC BACKGROUND; PLASMACYTOSIS;
D O I：
10.1073/pnas.89.1.232
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The mechanisms through which pristane or mineral oil can induce plasmacytomas in BALB/c or NZB mice are not fully understood, but involvement of interleukin 6 (IL-6), a growth factor for plasmacytomas and myelomas, has been strongly suggested. To clarify the role of IL-6 in plasmacytomagenesis, a human IL-6 cDNA was introduced into mouse germ lines under the transcriptional control of the murine major histocompatibility complex class I (H-2L(d)) promoter. IL-6 transgenic mice of C57BL/6 origin developed a massive plasmacytosis but not plasmacytomas. However, introduction of BALB/c genetic background into IL-6 transgenic mice could generate monoclonal transplantable plasmacytomas with the chromosomal translocation t(12;15). These results provide firm evidence of the critical role of IL-6 in the plasmacytoma development.
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收藏
页码：232 / 235
页数：4
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